The detection of alkylation damage in the DNA of human gastrointestinal tissues.

@article{Hall1991TheDO,
  title={The detection of alkylation damage in the DNA of human gastrointestinal tissues.},
  author={C Nicholas Hall and Alaa Badawi and Peter J. O'Connor and R. Saffhill},
  journal={British Journal of Cancer},
  year={1991},
  volume={64},
  pages={59 - 63}
}
Damage arising from putative environmental sources has been found in the DNA of the gastric and colorectal mucosae of patients presenting with gastrointestinal disorders from the South Manchester area. O6-Methylguanine (O6-MeG) in the range 0.010- greater than 0.300 mu moles mole-1 adenine was heterogeneously distributed both between and within individuals. The pattern of alkylation of tissue DNA appears to differ when comparison is made between gastric and colorectal samples. Most of the… CONTINUE READING
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06-Alkylguanine DNA-alkyltransferase: significance, methods of measurement

  • G. P. MARGISON, P. J. O'CONNOR, D. P. COOPER
  • 1990

Cell and tissue

  • FAN, C.-Y, W. H. BUTLER, P. J. O'CONNOR
  • 1989

Immunoanalytical detection of 04-ethylthymine in liver DNA of individuals with or without malignant tumours

  • T. KUROKI
  • Cancer Res.,
  • 1989

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