The detection and characterisation of collagenase inhibitors from rabbit tissues in culture.

@article{Murphy1977TheDA,
  title={The detection and characterisation of collagenase inhibitors from rabbit tissues in culture.},
  author={Gillian Murphy and Elizabeth Cartwright and A. Martin Sellers and J. Joshua Reynolds},
  journal={Biochimica et biophysica acta},
  year={1977},
  volume={483 2},
  pages={
          493-8
        }
}
As tissue cultures, rabbit bone, skin and non-gravid uterus synthesise inhibitors of collagenase (EC 3.4.24.3). An assay for the inhibitors is described and their action on collagenase from different tissue sources demonstrated. Evidence for the involvement of the tissue inhibitors of collagenase in the latency of the enzyme in culture media is presented. Latent collagenase was activated by treatment with 4-aminophenylmercuric acetate, and then reacted with the inhibitors to form inactive… CONTINUE READING
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