The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models.

@article{Szab2010TheDP,
  title={The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models.},
  author={D{\'o}ra Szab{\'o} and Eszter Ostorh{\'a}zi and Annegret Binas and Ferenc Rozgonyi and B{\'e}la Kocsis and Marco Cassone and John D Wade and Oliver Nolte and Laszlo Jr Otvos},
  journal={International journal of antimicrobial agents},
  year={2010},
  volume={35 4},
  pages={357-61}
}
Antimicrobial peptides are considered to be viable alternatives to conventional antibiotics. However, they rarely show systemic efficacy in animal models when added at non-toxic doses. The dimer A3-APO was designed to attack both the bacterial membrane and the Enterobacteriaceae-specific domain of the heat shock protein DnaK in order to reduce toxicity whilst maintaining activity. The peptide exhibited a minimal inhibitory concentration (MIC) range of 2-128 mg/L against 28 clinical Escherichia… CONTINUE READING
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