The design of scaffolds for use in tissue engineering. Part I. Traditional factors.

@article{Yang2001TheDO,
  title={The design of scaffolds for use in tissue engineering. Part I. Traditional factors.},
  author={S Yang and Kah Fai Leong and Z. H. Du and Chee Kai Chua},
  journal={Tissue engineering},
  year={2001},
  volume={7 6},
  pages={
          679-89
        }
}
  • S. YangK. Leong C. Chua
  • Published 1 December 2001
  • Biology, Engineering, Materials Science
  • Tissue engineering
In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and… 

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References

SHOWING 1-10 OF 63 REFERENCES

The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques.

The authors review the application and advancement of rapid prototyping (RP) techniques in the design and creation of synthetic scaffolds for use in TE and the advantages and benefits, and limitations and shortcomings of current RP techniques as well as the future direction of RP development in TE scaffold fabrication.

Tissue Engineering Cartilage and Bone

Tissue engineering is an emerging multidisciplinary field in which the material properties of synthetic compounds are manipulated to enable delivery of an aggregate of dissociated cells into a host

Tissue engineering by cell transplantation using degradable polymer substrates.

This paper reviews our research in developing novel matrices for cell transplantation using bioresorbable polymers. We focus on applications to liver and cartilage as paradigms for regeneration of

The importance of new processing techniques in tissue engineering.

The discussion of polymer-scaffold processing explains fiber bonding, solvent casting and particulate leaching, membrane lamination, melt molding, polymer/ceramic fiber composite-foam processing, phase separation, and high-pressure processing.

Design of synthetic polymeric structures for cell transplantation and tissue engineering.

Pore Morphology Effects on the Fibrovascular Tissue Growth in Porous Polymer Substrates

The feasibility of developing biodegradable polymer scaffolds to engineer tissues was investigated by studying the effects of pore size on the dynamics of fibrovascular tissue ingrowth, holding promise in the regeneration of tubular tissues by relying on the epithelization of prevascularized grafts.

Tissue Engineering of Bone

Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation.

A novel method was developed to prepare three-dimensional structures with desired shapes used as templates for cell transplantation. The produced biomaterials are highly porous with large

Tissue engineering of bone

Important aspects, such as osteogenic cells, matrix materials, inter- and intra-cellular communication, growth factors, gene therapy and current concepts of bone tissue engineering are reviewed and first clinical applications are discussed.
...