The design of effective in vivo antagonists of rat uterus and milk ejection responses to oxytocin.

@article{Sawyer1980TheDO,
  title={The design of effective in vivo antagonists of rat uterus and milk ejection responses to oxytocin.},
  author={W. H. Sawyer and J. Haldar and D. Gazis and J. Seto and K. Bańkowski and J. Lowbridge and A. Tur{\'a}n and M. Manning},
  journal={Endocrinology},
  year={1980},
  volume={106 1},
  pages={
          81-91
        }
}
  • W. H. Sawyer, J. Haldar, +5 authors M. Manning
  • Published 1980
  • Biology, Medicine
  • Endocrinology
  • Several new synthetic analogs of the oxytocin antagonist [1-deaminopenicillamine]oxytocin have been prepared and tested for their abilities to inhibit responses to oxytocin by the isolated rat uterus in the absence and presence of Mg++, by the rat uterus in situ, and by the rat mammary gland in situ. Substituting 2-O-methyltyrosine in [1-deaminopenicillamine]oxytocin strikingly enhances antagonism of all uterin responses, and [1-deaminopenicillamine, 2-O-methyltyrosine]oxytocin and its 4… CONTINUE READING
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