The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

@article{Rodrguez2010TheDO,
  title={The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid},
  author={E. Rodr{\'i}guez and J. Bl{\'a}zquez and M. Guerra},
  journal={Peptides},
  year={2010},
  volume={31},
  pages={757-776}
}
  • E. Rodríguez, J. Blázquez, M. Guerra
  • Published 2010
  • Biology, Medicine
  • Peptides
  • The blood-brain barrier (BBB) is a single uninterrupted barrier that in the brain capillaries is located at the endothelial cells and in the circumventricular organs, such as the choroid plexuses (CP) and median eminence (ME), is displaced to specialized ependymal cells. How do hypothalamic hormones reach the portal circulation without making the BBB leaky? The ME milieu is open to the portal vessels, while it is closed to the cerebrospinal fluid (CSF) and to the arcuate nucleus. The cell body… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 150 REFERENCES
    A second look at the barriers of the medial basal hypothalamus
    • 266
    • Highly Influential
    • PDF
    Sexual dimorphism in the organization of the rat hypothalamic infundibular area
    • 109
    Transport function of hypothalamic tanycyte ependyma: How good is the evidence?
    • 57
    Protein components of the blood–brain barrier (BBB) in the mediobasal hypothalamus
    • 107
    The functional and structural border of the neurohemal region of the median eminence
    • 55
    • Highly Influential