The design of an enzyme: a chronology on the controversy.

  • Henri Buc
  • Published 2013 in Journal of molecular biology


After the publication of the Monod-Wyman-Changeux model, a controversy arose between Jacques Monod, Francis Crick and Jeffries Wyman about the comparison of the regulatory performances of an oligomer undergoing a concerted transition between two states and a monomer having the same composition and subjected to a similar conformational equilibrium. The… (More)
DOI: 10.1016/j.jmb.2013.03.015