The design of an adaptive clinical trial to evaluate the efficacy of platelets stored at low temperature in surgical patients.

Abstract

BACKGROUND Storage of platelets at 4°C compared with 22°C may increase both hemostatic activity and storage duration; however, the maximum duration of cold storage is unknown. We report the design of an innovative, prospective, randomized, Bayesian adaptive, "duration finding" clinical trial to evaluate the efficacy and maximum duration of storage of… (More)
DOI: 10.1097/TA.0000000000001876

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