The design and use of animal models for translational research in bone tissue engineering and regenerative medicine.

@article{Muschler2010TheDA,
  title={The design and use of animal models for translational research in bone tissue engineering and regenerative medicine.},
  author={George F. Muschler and Vivek P Raut and Thomas E. Patterson and Joseph C. Wenke and Jeffrey O. Hollinger},
  journal={Tissue engineering. Part B, Reviews},
  year={2010},
  volume={16 1},
  pages={123-45}
}
This review provides an overview of animal models for the evaluation, comparison, and systematic optimization of tissue engineering and regenerative medicine strategies related to bone tissue. This review includes an overview of major factors that influence the rational design and selection of an animal model. A comparison is provided of the 10 mammalian species that are most commonly used in bone research, and existing guidelines and standards are discussed. This review also identifies gaps in… CONTINUE READING
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