The design and synthesis of noncovalent factor Xa inhibitors.

  title={The design and synthesis of noncovalent factor Xa inhibitors.},
  author={Mimi L Quan and Ruth R Wexler},
  journal={Current topics in medicinal chemistry},
  volume={1 2},
Thrombosis is a major cause of mortality in the industrialized world. Therefore, the control of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (fXa), the enzyme directly responsible for thrombin generation. In this review we describe our approaches in the design and synthesis of small molecule, noncovalent fXa inhibitors. Rational drug design and selective screening of our GPIIb/IIIa library afforded several lead… CONTINUE READING

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