The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase.

Abstract

Soluble guanylate cyclase (sGC) is highly activated in the presence of both YC-1 (1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole) and CO. In this report, the design, synthesis, and activity (i.e., sGC activation) of photolabile analogues of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) are presented. Initial results with 6-azido-3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole led to the synthesis of a tritium-labeled analogue. When photoactivated, this analogue labeled the alpha-subunit of sGC.

Cite this paper

@article{Hering2006TheDA, title={The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase.}, author={Kirk W Hering and Jennifer D. Artz and William H Pearson and Michael A Marletta}, journal={Bioorganic & medicinal chemistry letters}, year={2006}, volume={16 3}, pages={618-21} }