The design and conduct of clinical trials to limit missing data.

@article{Little2012TheDA,
  title={The design and conduct of clinical trials to limit missing data.},
  author={Roderick J. A. Little and Morris L. Cohen and Kay Dickersin and Scott S. Emerson and Jonathan Farrar and James D. Neaton and Wen-Li Shih and Jay P Siegel and Hal Stern},
  journal={Statistics in medicine},
  year={2012},
  volume={31 28},
  pages={3433-43}
}
This article summarizes recommendations on the design and conduct of clinical trials of a National Research Council study on missing data in clinical trials. Key findings of the study are that (a) substantial missing data is a serious problem that undermines the scientific credibility of causal conclusions from clinical trials; (b) the assumption that analysis methods can compensate for substantial missing data is not justified; hence (c) clinical trial design, including the choice of key… CONTINUE READING

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