The design and conduct of clinical trials to limit missing data.

  title={The design and conduct of clinical trials to limit missing data.},
  author={R. Little and M. L. Cohen and K. Dickersin and S. Emerson and J. Farrar and J. Neaton and W. Shih and J. Siegel and H. Stern},
  journal={Statistics in medicine},
  volume={31 28},
  • R. Little, M. L. Cohen, +6 authors H. Stern
  • Published 2012
  • Medicine
  • Statistics in medicine
  • This article summarizes recommendations on the design and conduct of clinical trials of a National Research Council study on missing data in clinical trials. Key findings of the study are that (a) substantial missing data is a serious problem that undermines the scientific credibility of causal conclusions from clinical trials; (b) the assumption that analysis methods can compensate for substantial missing data is not justified; hence (c) clinical trial design, including the choice of key… CONTINUE READING
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