The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor.

@article{Reggio1995TheDS,
  title={The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor.},
  author={Patricia H. Reggio and R D Bramblett and H Yuknavich and Herbert H Seltzman and Denise N. Fleming and Susanthi R. Fernando and Lesley A. Stevenson and Roger G. Pertwee},
  journal={Life sciences},
  year={1995},
  volume={56 23-24},
  pages={
          2025-32
        }
}
Cannabidiol CBD, a non-psychoactive constituent of marihuana, has been reported to possess essentially no affinity for cannabinoid CB1 receptor binding sites in the brain. Our hypothesis concerning CBD's lack of affinity for the cannabinoid CB1 receptor is that CBD is not capable of clearing a region of steric interference at the CB1 receptor and thereby not able to bind to this receptor. We have previously characterized this region of steric interference at the CB1 receptor [P.H. Reggio, A.M… Expand
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