The design, synthesis and in vitro immunosuppressive evaluation of novel isobenzofuran derivatives.

Abstract

The synthesis and biological evaluation of a series of novel isobenzofuran-based compounds are described. The compounds were evaluated for their immunosuppressive effects of T-cell proliferation and IMPDH type II inhibitor activity in vitro, as well as their structure-activity relationships were assessed. Several compounds demonstrated highly efficacious… (More)
DOI: 10.1016/j.bmcl.2011.11.078

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