The dermorphin peptide family.

  title={The dermorphin peptide family.},
  author={Pietro Melchiorri and Lucia Negri},
  journal={General pharmacology},
  volume={27 7},
1. In 1980, the skin of certain frogs belonging to the genus Phyllomedusinae was found to contain two new peptides that proved to be selective mu-opioid agonists. Given the name dermorphins, these were the first members of a peptide family that in the past 15 years has grown to reach a total of seven naturally occurring peptides and nearly 30 synthetic analogs. 2. Dermorphin peptides are potent analgesics in rodents and primates, including man. Some dermorphins can enter the blood-brain barrier… CONTINUE READING

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