The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734

@inproceedings{Feetham2015TheDR,
  title={The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734},
  author={Claire H. Feetham and Nicolas Nunn and Richard Barrett-Jolley},
  booktitle={Front. Pharmacol.},
  year={2015}
}
Several reports have shown that the periventricular region of the brain, including the paraventricular nucleus (PVN), is critical to sensing and responding to changes in plasma osmolality. Further studies also implicate the transient receptor potential ion channel, type V4 (TRPV4) channel in this homeostatic behavior. In previous work we have shown that TRPV4 ion channels couple to calcium-activated potassium channels in the PVN to decrease action potential firing frequency in response to… CONTINUE READING
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Disrupting sensitization of TRPV4

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TRPV4 is associated with central rather than nephrogenic osmoregulation

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  • 2016
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TRPV4: Molecular Conductor of a Diverse Orchestra.

  • Physiological reviews
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