The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734

@article{Feetham2015TheDR,
  title={The depressor response to intracerebroventricular hypotonic saline is sensitive to TRPV4 antagonist RN1734},
  author={C. Feetham and N. Nunn and R. Barrett-Jolley},
  journal={Frontiers in Pharmacology},
  year={2015},
  volume={6}
}
Several reports have shown that the periventricular region of the brain, including the paraventricular nucleus (PVN), is critical to sensing and responding to changes in plasma osmolality. Further studies also implicate the transient receptor potential ion channel, type V4 (TRPV4) channel in this homeostatic behavior. In previous work we have shown that TRPV4 ion channels couple to calcium-activated potassium channels in the PVN to decrease action potential firing frequency in response to… Expand
9 Citations
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