The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth.

@article{Caibano2007TheDR,
  title={The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth.},
  author={Carmen Ca{\~n}ibano and Noela L Rodriguez and Carmen S{\'a}ez and S. {\'O}scar Tovar and Montse Garcia-Lavandeira and Maria Grazia Borrello and A. -M. Vidal and Frank D. Costantini and Miguel {\'A}. Jap{\'o}n and Carlos Di{\'e}guez and Clara V. Alvarez},
  journal={The EMBO journal},
  year={2007},
  volume={26 8},
  pages={2015-28}
}
Somatotrophs are the only pituitary cells that express Ret, GFRalpha1 and GDNF. This study investigated the effects of Ret in a somatotroph cell line, in primary pituitary cultures and in Ret KO mice. Ret regulates somatotroph numbers by inducing Pit-1 overexpression, leading to increased p53 expression and apoptosis, both of which can be prevented with Ret or Pit-1 siRNA. The Pit-1 overexpression is mediated by sustained activation of PKCdelta, JNK, c/EBPalpha and CREB induced by a complex of… CONTINUE READING
29 Citations
48 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…