The dependence of the maximum rate of rise of the action potential upstroke on membrane properties.

@article{Cohen1981TheDO,
  title={The dependence of the maximum rate of rise of the action potential upstroke on membrane properties.},
  author={Ira Cohen and David Attwell and Gary R. Strichartz},
  journal={Proceedings of the Royal Society of London. Series B, Biological sciences},
  year={1981},
  volume={214 1194},
  pages={85-98}
}
The maximum rate of rise of the action potential (Vmax) is often used to study the maximum sodium conductance (GNa) of excitable membranes, by assuming that Vmax is proportional to GNa. However, the real relation between Vmax and GNa is uncertain. We use simple analytical descriptions of the membrane currents to investigate this relation. If (1) the sodium conductance is greater than the non-sodium conductance of the membrane, (2) the sodium current is activated extremely quickly, and (3) the… CONTINUE READING

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