The dependence of motoneurons on their target muscle during postnatal development of the mouse.

@article{Crews1990TheDO,
  title={The dependence of motoneurons on their target muscle during postnatal development of the mouse.},
  author={Leslie Crews and Donald J. Wigston},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1990},
  volume={10 5},
  pages={1643-53}
}
Motoneurons seem to require contact with their target muscle even after embryogenesis is complete, but the consequences of target-deprivation during postnatal development are poorly understood. To examine the fate of motoneurons separated from their targets postnatally, we labeled the motoneurons that innervate the biceps brachii muscle with the retrograde tracer Fluorogold and then separated them from their muscle by amputating the forelimb. Fluorogold was subsequently found within motoneurons… CONTINUE READING
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