The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

  title={The density of small tight junction pores varies among cell types and is increased by expression of claudin-2},
  author={Christina M Van Itallie and Jennifer L Holmes and Arlene S. Bridges and Jody L. Gookin and Mariarosa Coccaro and William Proctor and Oscar R. Colegio and James M. Anderson},
  journal={Journal of Cell Science},
  pages={298 - 305}
Epithelial tight junctions contain size- and charge-selective pores that control the paracellular movement of charged and noncharged solutes. Claudins influence the charge selectivity and electrical resistance of junctions, but there is no direct evidence describing pore composition or whether pore size or density differs among cell types. To characterize paracellular pores independent of influences from charge selectivity, we profiled the `apparent permeabilities' (Papp) of a continuous series… 

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