The dengue virus conceals double-stranded RNA in the intracellular membrane to escape from an interferon response

Abstract

The dengue virus (DENV) circulates between humans and mosquitoes and requires no other mammals or birds for its maintenance in nature. The virus is well-adapted to humans, as reflected by high-level viraemia in patients. To investigate its high adaptability, the DENV induction of host type-I interferon (IFN) was assessed in vitro in human-derived HeLa cells… (More)
DOI: 10.1038/srep07395

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