The dendritic cell mannose receptor mediates allergen internalization and maturation involving notch 1 signalling.

@article{Li2010TheDC,
  title={The dendritic cell mannose receptor mediates allergen internalization and maturation involving notch 1 signalling.},
  author={Juan Li and Han-dong Jiang and Wei-hong Wen and Jiarong Zheng and Guofeng Xu},
  journal={Clinical and experimental immunology},
  year={2010},
  volume={162 2},
  pages={251-61}
}
Dendritic cells (DCs) have been shown recently to play a key role in inducing and mediating T helper type 2 (Th2) responses associated with atopic disease. These responses are mediated in part by ligation to different Toll-like receptors (TLRs) and C-type lectins, e.g. the mannose receptor (MR), depending upon the DC subset involved and the respective microenvironments. Because ovalbumin (OVA) (which is structurally related to various allergens) can engage the MR, we can use OVA stimulation as… CONTINUE READING

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