The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.

@article{Merad2013TheDC,
  title={The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.},
  author={Miriam Merad and Priyanka Sathe and Julie Helft and Jennifer Miller and Arthur Mortha},
  journal={Annual review of immunology},
  year={2013},
  volume={31},
  pages={563-604}
}
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major… CONTINUE READING
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