The denatured state (the other half of the folding equation) and its role in protein stability
@article{Shortle1996TheDS,
title={The denatured state (the other half of the folding equation) and its role in protein stability},
author={David R. Shortle},
journal={The FASEB Journal},
year={1996},
volume={10},
pages={27 - 34}
}Experimental studies of the physical interactions that stabilize protein structure are complicated by the fact that proteins do not unfold to a simple reference state. When their folded structure breaks down, protein chains do not become random coils. Instead, they enter a poorly understood ensemble of partially folded states known collectively as the denatured state. Although it has long been held that agents that promote protein unfolding act specifically oh the denatured state, the idea that…
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