The demographics of the ubiquitin system.

  title={The demographics of the ubiquitin system.},
  author={Michael J Clague and Claire Heride and Sylvie Urb{\'e}},
  journal={Trends in cell biology},
  volume={25 7},
The ubiquitin system is a major coordinator of cellular physiology through regulation of both protein degradation and signalling pathways. A key building block of a systems-level understanding has been generated by global proteomic studies, which provide copy number estimates for each component. The aggregate of ubiquitin, conjugating enzymes (E1, E2, and E3s), and deubiquitylases (DUBs) represents ∼1.3% of total cellular protein. Complementary approaches have generated quantitative… CONTINUE READING
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