The demethylation of methamphetamine by intestinal microflora

@article{Caldwell1973TheDO,
  title={The demethylation of methamphetamine by intestinal microflora},
  author={John Caldwell and Gabrielle M. Hawksworth},
  journal={Journal of Pharmacy and Pharmacology},
  year={1973},
  volume={25}
}
Methamphetamine (2-methylamino-1-phenylpropane) is a sympathomimetic drug which is liable to serious abuse (Kramer, Fischman & Littlefield, 1967). Its metabolism in the rat, guinea-pig and man has been described (Caldwell, Dring & Williams, 1972 a, b; Dring & Caldwell, 1973). These authors found that the route of elimination of [14C] methamphetamine by guinea-pigs varied with the dose administered. With a dose of 10 mg kg-l, 84% of 14C appeared in the urine with 3 % in the faeces, but at a dose… Expand
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