The demethylation of methamphetamine by intestinal microflora

  title={The demethylation of methamphetamine by intestinal microflora},
  author={John Caldwell and Gabrielle M. Hawksworth},
  journal={Journal of Pharmacy and Pharmacology},
Methamphetamine (2-methylamino-1-phenylpropane) is a sympathomimetic drug which is liable to serious abuse (Kramer, Fischman & Littlefield, 1967). Its metabolism in the rat, guinea-pig and man has been described (Caldwell, Dring & Williams, 1972 a, b; Dring & Caldwell, 1973). These authors found that the route of elimination of [14C] methamphetamine by guinea-pigs varied with the dose administered. With a dose of 10 mg kg-l, 84% of 14C appeared in the urine with 3 % in the faeces, but at a dose… Expand
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It is indicated that brain levorphanol concentrations resulting from administration of PMM or pOH-PMM to rats may account for the analgesic activity observed, i.e. that PMM and pOH -PMM may act as prodrugs forlevorphanol. Expand
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It was found that the medium in which the organism was grown had a significant effect on the N-demethylase activity observed, and more than half of the enteric bacteria studied were capable of N- Demethylating imipramine (I) to desipramines (II) to some extent in at least one medium. Expand
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Metabolism of [14C]methamphetamine in man, the guinea pig and the rat
1. The metabolites of (+/-)-2-methylamino-1-phenyl[1-(14)C]propane ([(14)C]methamphetamine) in urine were examined in man, rat and guinea pig. 2. In two male human subjects receiving the drug orallyExpand
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Application of Buffered Solvent Systems to the Detection of Aromatic Acids by Paper Partition Chromatography
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