The delta subunit of DNA polymerase III holoenzyme serves as a sliding clamp unloader in Escherichia coli.

@article{Leu2000TheDS,
  title={The delta subunit of DNA polymerase III holoenzyme serves as a sliding clamp unloader in Escherichia coli.},
  author={Frank P Leu and Manju M Hingorani and Jeremy Turner and Mike O'Donnell},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 44},
  pages={
          34609-18
        }
}
In Escherichia coli, the circular beta sliding clamp facilitates processive DNA replication by tethering the polymerase to primer-template DNA. When synthesis is complete, polymerase dissociates from beta and DNA and cycles to a new start site, a primed template loaded with beta. DNA polymerase cycles frequently during lagging strand replication while synthesizing 1-2-kilobase Okazaki fragments. The clamps left behind remain stable on DNA (t(12) approximately 115 min) and must be removed… CONTINUE READING
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