The delta-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine.

@article{Shippenberg1995TheDR,
  title={The delta-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine.},
  author={T. S. Shippenberg and Christian A. Heidbreder},
  journal={European journal of pharmacology},
  year={1995},
  volume={280 1},
  pages={55-61}
}
A conditioned place preference paradigm was used to determine whether: (i) prior exposure to cocaine results in an enhancement of its rewarding effects, and (ii) the delta-opioid receptor antagonist naltrindole can prevent the development of this response. Rats received daily injections of saline or cocaine (10.0 mg/kg i.p.) for 5 days in the colony room. Additional animals received naltrindole (0.03-0.3 mg/kg s.c.), lithium chloride (20 mg/kg s.c.) or vehicle prior to i.p. injections… CONTINUE READING

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