The deleterious or beneficial effects of different agents in intracerebral hemorrhage: think big, think small, or is hematoma size important?


BACKGROUND AND PURPOSE Thrombin, heme oxygenase, complement, microglia activation, and leukocyte infiltration are all actively upregulated in intracerebral hemorrhage (ICH). Experimental evidence suggests that all these factors are involved in ICH-induced brain injury. This suggests a scenario whereby ICH actively (through gene and protein upregulation… (More)


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