The delayed lung responses to single and repeated intratracheal administration of pure cobalt and hard metal powder in the rat.

@article{Lasfargues1995TheDL,
  title={The delayed lung responses to single and repeated intratracheal administration of pure cobalt and hard metal powder in the rat.},
  author={G{\'e}rard Lasfargues and C{\'e}cile Lardot and Monique A. Delos and Robert Lauwerys and Dominique Lison},
  journal={Environmental research},
  year={1995},
  volume={69 2},
  pages={
          108-21
        }
}
Epidemiological and clinical studies suggest that inhalation of cobalt metal dust (Co) mixed with tungsten carbide particles (WC), but not of cobalt dust alone, may cause interstitial pulmonary lesions (hard metal disease). In previous experimental studies in the rat, we have demonstrated the greater acute pulmonary toxicity of a WC-Co mixture compared to Co or WC alone. The present study was undertaken to compare in the same animal model the delayed lung response after intratracheal… CONTINUE READING
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