The degradation of type II collagen in rheumatoid arthritis: an immunoelectron microscopic study.

@article{Dodge1991TheDO,
  title={The degradation of type II collagen in rheumatoid arthritis: an immunoelectron microscopic study.},
  author={George R. Dodge and Isabelle Pidoux and A. Robin Poole},
  journal={Matrix},
  year={1991},
  volume={11 5},
  pages={330-8}
}
Rabbit antibodies were prepared that react only with denatured type II collagen alpha-chains and cleavage products. The epitopes that these antibodies recognize reside in cyanogen bromide peptides CB8 and CB11. The antibodies do not react with triple helical collagen nor with any other collagen or protein present in hyaline cartilage (Dodge and Poole, J. Clin. Invest. 83:647-661, 1989). These antibodies can therefore be used to detect denatured type II collagen produced, for example, by… CONTINUE READING

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