The degradation of dynorphin A in brain tissue in vivo and in vitro.

@article{Young1987TheDO,
  title={The degradation of dynorphin A in brain tissue in vivo and in vitro.},
  author={Elizabeth Anne Young and Jennifer M. Walker and Richard A. Houghten and Huda Akil},
  journal={Peptides},
  year={1987},
  volume={8 4},
  pages={701-7}
}
The demonstration of analgesia following in vivo administration of dynorphin A (Dyn A) has been difficult. In contrast, a number of electrophysiological and behavioral effects reported with in vivo injection of Dyn A can be produced by des-tyrosine dynorphin A (Dyn A 2-17). This suggested the extremely rapid amino terminal degradation of dynorphin A. To… CONTINUE READING