The degradation and clearance of Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent.

@article{Zhang2012TheDA,
  title={The degradation and clearance of Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent.},
  author={Guodong Zhang and Rui Zhang and Marites P. Melancon and Kelvin Wong and Jian You and Qian Huang and James A Bankson and Dong Liang and Chun Li},
  journal={Biomaterials},
  year={2012},
  volume={33 21},
  pages={
          5376-83
        }
}
Although polymeric magnetic resonance imaging (MRI) agents have significantly improved relaxivity and prolonged circulation time in vivo compared with current imaging agents, the potential for long-term toxicity prevents their translation into the clinic. The aim of this study was to develop a new biodegradable, nonionic polymeric blood pool MRI contrast agent with efficient clearance from the body. We synthesized PHPG-DTPA, which possesses two potentially degradable sites in vivo: protein… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Magnetic resonance imaging of therapy-induced necrosis using gadolinium-chelated polyglutamic acids.

International journal of radiation oncology, biology, physics • 2007
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