The degenerate Y chromosome--can conversion save it?

@article{Graves2004TheDY,
  title={The degenerate Y chromosome--can conversion save it?},
  author={J. Graves},
  journal={Reproduction, fertility, and development},
  year={2004},
  volume={16 5},
  pages={
          527-34
        }
}
  • J. Graves
  • Published 2004
  • Biology, Medicine
  • Reproduction, fertility, and development
The human Y chromosome is running out of time. In the last 300 million years, it has lost 1393 of its original 1438 genes, and at this rate it will lose the last 45 in a mere 10 million years. But there has been a proposal that perhaps rescue is at hand in the form of recently discovered gene conversion within palindromes. However, I argue here that although conversion will increase the frequency of variation of the Y (particularly amplification) between Y chromosomes in a population, it will… Expand
Sex Chromosomes Evolution in Mammals
TLDR
The latest findings have revealed that mam‑ malian sex chromosomes evolved from a pair of autosome 166 million years ago and in two groups of rodents the mole vole and the Japanese spiny rat the Y chromosome has been removed completely and a new sex determination system has evolved. Expand
Can Intra-Y Gene Conversion Oppose the Degeneration of the Human Y Chromosome? A Simulation Study
TLDR
Simulating the evolution of degenerating Y chromosomes with or without gene conversion using the most up-to-date population genetics parameters for humans showed that Y–Y gene conversion may be beneficial in most mammalian species, which is consistent with recent data in chimpanzees and mice. Expand
Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
TLDR
DNA sequences of unique, Y-linked genes in chimpanzee and human, which diverged about six million years ago, are compared to find evidence that in the human lineage, all such genes were conserved through purifying selection. Expand
The Biology and Evolution of Mammalian Y Chromosomes.
TLDR
A third biological theme begins to emerge from recent insights into the Y chromosome's roles beyond the reproductive tract--a theme that promises to broaden the reach of Y-chromosome research by shedding light on fundamental sex differences in human health and disease. Expand
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration
  • D. Bachtrog
  • Biology, Medicine
  • Nature Reviews Genetics
  • 2013
TLDR
Comparison of young and old Y chromosomes has given further insights into the evolutionary and molecular forces triggering Y-chromosome degeneration and into the Darwinian destiny of the Y chromosome. Expand
The Temporal Dynamics of Processes Underlying Y Chromosome Degeneration
TLDR
The temporal dynamics of these processes imply that a gradual restriction of recombination, as inferred in mammals, will increase the importance of genetic hitchhiking relative to Muller's ratchet and background selection. Expand
Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster
TLDR
All these Y-related phenotypes are described and a potential similarity with the human Y chromosome is drawn. Expand
Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster
TLDR
All these Y-related phenotypes are described and a potential similarity with the human Y chromosome is drawn. Expand
Sex, rebellion and decadence: the scandalous evolutionary history of the human Y chromosome.
TLDR
Understanding to what extent the idiosyncrasies of Y recombination may impact this chromosome's role in sex determination and male germline functions should be regarded as essential for added clinical insight into several male infertility phenotypes. Expand
Compact but Complex – The Marsupial Y Chromosome
TLDR
The unique properties of the marsupial Y chromosome have provided insights into the evolution of the mammalian Y, enabling us to gain a better understanding of the selection processes that shaped it. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
Evolution of the mammalian Y chromosome and sex-determining genes.
  • J. Graves
  • Biology, Medicine
  • The Journal of experimental zoology
  • 1998
TLDR
It is suggested here that, rather than acting as a transcriptional activator, the SRY gene acts to inhibit its paralogue SOX3, which in turn inhibits an ancient autosomal sex-determining gene SOX9. Expand
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection
TLDR
It is suggested that the existence of this deletion as a polymorphism reflects a balance between haploid selection, which culls gr/gr-deleted Y chromosomes from the population, and homologous recombination, which continues to generate newgr/gr deletions. Expand
The rise and fall of SRY.
TLDR
Comparisons between species reveal when and how SRY, the testis-determining gene, evolved, and how it is dispensable, having been lost at least twice independently in different rodent lineages. Expand
The origin and function of the mammalian Y chromosome and Y‐borne genes – an evolving understanding
  • J. Graves
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1995
TLDR
The addition–attrition hypothesis predicts that the pseudoautosomal region of the human X is merely the last relic of the latest addition, and evolved functions in male sex determination and differentiation distinct from the general functions of their X‐linked partners. Expand
The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome.
TLDR
The findings indicate that UBE1 lies within the X-Y pairing segment of the platypus but is absent from the human Y chromosome, having been lost from the Y chromosome during evolution of the primate lineage. Expand
Abundant gene conversion between arms of palindromes in human and ape Y chromosomes
TLDR
It is concluded that during recent evolution, an average of approximately 600 nucleotides per newborn male have undergone Y–Y gene conversion, which has had an important role in the evolution of multi-copy testis gene families in the MSY. Expand
THE ACCUMULATION OF SEXUALLY ANTAGONISTIC GENES AS A SELECTIVE AGENT PROMOTING THE EVOLUTION OF REDUCED RECOMBINATION BETWEEN PRIMITIVE SEX CHROMOSOMES
  • W. Rice
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 1987
TLDR
It is concluded that very tight linkage is not required for the accumulation of genes that are lethal or semilethal to the homogametic sex, as a function of their recombinational distance from the sex locus. Expand
Embryonic growth and the evolution of the mammalian Y chromosome. I. The Y as an attractor for selfish growth factors
TLDR
Data from mice and humans indicate that the mammalian Y chromosome is expected to be an attractor for growth-promoting genes, and the accumulation of Y-linked genes may also be explained in terms of sexual antagonism. Expand
Strong male-driven evolution of DNA sequences in humans and apes
TLDR
This study reinstates a high α in hominoids and supports the view that DNA replication errors are the primary source of germline mutation and suggests that closely related species are not suitable for estimating α. Expand
Four evolutionary strata on the human X chromosome.
TLDR
The ages of individual X-Y gene pairs and the locations of their X members on the X chromosome were found to be highly correlated and age decreased in stepwise fashion from thedistal long arm to the distal short arm in at least four "evolutionary strata". Expand
...
1
2
3
4
5
...