The degenerate Y chromosome--can conversion save it?

@article{Graves2004TheDY,
  title={The degenerate Y chromosome--can conversion save it?},
  author={J. Graves},
  journal={Reproduction, fertility, and development},
  year={2004},
  volume={16 5},
  pages={
          527-34
        }
}
  • J. Graves
  • Published 2004
  • Biology, Medicine
  • Reproduction, fertility, and development
The human Y chromosome is running out of time. In the last 300 million years, it has lost 1393 of its original 1438 genes, and at this rate it will lose the last 45 in a mere 10 million years. But there has been a proposal that perhaps rescue is at hand in the form of recently discovered gene conversion within palindromes. However, I argue here that although conversion will increase the frequency of variation of the Y (particularly amplification) between Y chromosomes in a population, it will… Expand
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Sex Chromosomes Evolution in Mammals
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The latest findings have revealed that mam‑ malian sex chromosomes evolved from a pair of autosome 166 million years ago and in two groups of rodents the mole vole and the Japanese spiny rat the Y chromosome has been removed completely and a new sex determination system has evolved. Expand
Can Intra-Y Gene Conversion Oppose the Degeneration of the Human Y Chromosome? A Simulation Study
TLDR
Simulating the evolution of degenerating Y chromosomes with or without gene conversion using the most up-to-date population genetics parameters for humans showed that Y–Y gene conversion may be beneficial in most mammalian species, which is consistent with recent data in chimpanzees and mice. Expand
Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
TLDR
DNA sequences of unique, Y-linked genes in chimpanzee and human, which diverged about six million years ago, are compared to find evidence that in the human lineage, all such genes were conserved through purifying selection. Expand
The Biology and Evolution of Mammalian Y Chromosomes.
TLDR
A third biological theme begins to emerge from recent insights into the Y chromosome's roles beyond the reproductive tract--a theme that promises to broaden the reach of Y-chromosome research by shedding light on fundamental sex differences in human health and disease. Expand
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration
  • D. Bachtrog
  • Biology, Medicine
  • Nature Reviews Genetics
  • 2013
TLDR
Comparison of young and old Y chromosomes has given further insights into the evolutionary and molecular forces triggering Y-chromosome degeneration and into the Darwinian destiny of the Y chromosome. Expand
The Temporal Dynamics of Processes Underlying Y Chromosome Degeneration
TLDR
The temporal dynamics of these processes imply that a gradual restriction of recombination, as inferred in mammals, will increase the importance of genetic hitchhiking relative to Muller's ratchet and background selection. Expand
Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster
TLDR
All these Y-related phenotypes are described and a potential similarity with the human Y chromosome is drawn. Expand
Multiple Roles of the Y Chromosome in the Biology of Drosophila melanogaster
TLDR
All these Y-related phenotypes are described and a potential similarity with the human Y chromosome is drawn. Expand
Sex, rebellion and decadence: the scandalous evolutionary history of the human Y chromosome.
TLDR
Understanding to what extent the idiosyncrasies of Y recombination may impact this chromosome's role in sex determination and male germline functions should be regarded as essential for added clinical insight into several male infertility phenotypes. Expand
Compact but Complex – The Marsupial Y Chromosome
TLDR
The unique properties of the marsupial Y chromosome have provided insights into the evolution of the mammalian Y, enabling us to gain a better understanding of the selection processes that shaped it. Expand
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