The degenerate Y chromosome--can conversion save it?
@article{Graves2004TheDY, title={The degenerate Y chromosome--can conversion save it?}, author={Jennifer A. Marshall Graves}, journal={Reproduction, fertility, and development}, year={2004}, volume={16 5}, pages={ 527-34 } }
The human Y chromosome is running out of time. In the last 300 million years, it has lost 1393 of its original 1438 genes, and at this rate it will lose the last 45 in a mere 10 million years. But there has been a proposal that perhaps rescue is at hand in the form of recently discovered gene conversion within palindromes. However, I argue here that although conversion will increase the frequency of variation of the Y (particularly amplification) between Y chromosomes in a population, it will…
42 Citations
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The latest findings have revealed that mam‑ malian sex chromosomes evolved from a pair of autosome 166 million years ago and in two groups of rodents the mole vole and the Japanese spiny rat the Y chromosome has been removed completely and a new sex determination system has evolved.
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References
SHOWING 1-10 OF 70 REFERENCES
Evolution of the mammalian Y chromosome and sex-determining genes.
- BiologyThe Journal of experimental zoology
- 1998
It is suggested here that, rather than acting as a transcriptional activator, the SRY gene acts to inhibit its paralogue SOX3, which in turn inhibits an ancient autosomal sex-determining gene SOX9.
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection
- BiologyNature Genetics
- 2003
It is suggested that the existence of this deletion as a polymorphism reflects a balance between haploid selection, which culls gr/gr-deleted Y chromosomes from the population, and homologous recombination, which continues to generate newgr/gr deletions.
The rise and fall of SRY.
- BiologyTrends in genetics : TIG
- 2002
Comparisons between species reveal when and how SRY, the testis-determining gene, evolved, and how it is dispensable, having been lost at least twice independently in different rodent lineages.
The origin and function of the mammalian Y chromosome and Y‐borne genes – an evolving understanding
- BiologyBioEssays : news and reviews in molecular, cellular and developmental biology
- 1995
The addition–attrition hypothesis predicts that the pseudoautosomal region of the human X is merely the last relic of the latest addition, and evolved functions in male sex determination and differentiation distinct from the general functions of their X‐linked partners.
The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome.
- BiologyHuman molecular genetics
- 1998
The findings indicate that UBE1 lies within the X-Y pairing segment of the platypus but is absent from the human Y chromosome, having been lost from the Y chromosome during evolution of the primate lineage.
Abundant gene conversion between arms of palindromes in human and ape Y chromosomes
- BiologyNature
- 2003
It is concluded that during recent evolution, an average of approximately 600 nucleotides per newborn male have undergone Y–Y gene conversion, which has had an important role in the evolution of multi-copy testis gene families in the MSY.
THE ACCUMULATION OF SEXUALLY ANTAGONISTIC GENES AS A SELECTIVE AGENT PROMOTING THE EVOLUTION OF REDUCED RECOMBINATION BETWEEN PRIMITIVE SEX CHROMOSOMES
- BiologyEvolution; international journal of organic evolution
- 1987
It is concluded that very tight linkage is not required for the accumulation of genes that are lethal or semilethal to the homogametic sex, as a function of their recombinational distance from the sex locus.
Embryonic growth and the evolution of the mammalian Y chromosome. I. The Y as an attractor for selfish growth factors
- BiologyHeredity
- 1994
Data from mice and humans indicate that the mammalian Y chromosome is expected to be an attractor for growth-promoting genes, and the accumulation of Y-linked genes may also be explained in terms of sexual antagonism.
Strong male-driven evolution of DNA sequences in humans and apes
- BiologyNature
- 2002
This study reinstates a high α in hominoids and supports the view that DNA replication errors are the primary source of germline mutation and suggests that closely related species are not suitable for estimating α.
Four evolutionary strata on the human X chromosome.
- BiologyScience
- 1999
The ages of individual X-Y gene pairs and the locations of their X members on the X chromosome were found to be highly correlated and age decreased in stepwise fashion from thedistal long arm to the distal short arm in at least four "evolutionary strata".