The definition and meaning of treatment-resistant depression.

  title={The definition and meaning of treatment-resistant depression.},
  author={Harold A. Sackeim},
  journal={The Journal of clinical psychiatry},
  volume={62 Suppl 16},
Most patients treated for an episode of unipolar or bipolar major depression are treatment resistant in the sense that the majority do not achieve full remission with the first somatic or psychosocial treatment they receive. Little attention has been given to formalizing criteria for evaluating the nature and extent of treatment resistance, even though determining the adequacy and outcome of prior treatment trials is key in clinical decision making about subsequent treatment. Furthermore… CONTINUE READING
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