The deep evolution of metazoan microRNAs

  title={The deep evolution of metazoan microRNAs},
  author={B. Wheeler and Alysha M Heimberg and Vanessa N. Moy and E. Sperling and T. W. Holstein and S. Heber and K. Peterson},
  journal={Evolution & Development},
  • B. Wheeler, Alysha M Heimberg, +4 authors K. Peterson
  • Published 2009
  • Medicine, Biology
  • Evolution & Development
  • SUMMARY microRNAs (miRNAs) are approximately 22‐nucleotide noncoding RNA regulatory genes that are key players in cellular differentiation and homeostasis. They might also play important roles in shaping metazoan macroevolution. Previous studies have shown that miRNAs are continuously being added to metazoan genomes through time, and, once integrated into gene regulatory networks, show only rare mutations within the primary sequence of the mature gene product and are only rarely secondarily… CONTINUE READING

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