The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma.

@article{Haug2010TheDO,
  title={The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma.},
  author={Sara J Haug and Takele Lakew and Gabremaskal Habtemariam and Wondu Alemayehu and Vicky Cevallos and Zhaoxia Zhou and Jenafir I. House and Kathryn J. Ray and Travis C. Porco and Tina Rutar and Jeremy D. Keenan and Thomas M. Lietman and Bruce D. Gaynor},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2010},
  volume={51 5},
  pages={571-4}
}
After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P <.001 ) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is… CONTINUE READING