The decline of fertility in male uremic patients is correlated with low expression of the cystic fibrosis transmembrane conductance regulator protein (CFTR) in human sperm.

@article{Xu2012TheDO,
  title={The decline of fertility in male uremic patients is correlated with low expression of the cystic fibrosis transmembrane conductance regulator protein (CFTR) in human sperm.},
  author={Hui Xu and Hong Ge Li and Long-gen Xu and Jun-Rong Zhang and Wen-Ying Chen and Qi-xian Shi},
  journal={Human reproduction},
  year={2012},
  volume={27 2},
  pages={340-8}
}
BACKGROUND The present study was designed to investigate the possible association between infertility of male uremic patients and expression of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in their sperm. METHODS Semen was collected and analyzed. Serum levels of FSH, LH and testosterone were measured by radioimmunoassay. The sperm CFTR expressions of 21 uremic patients and 15 renal transplant patients were measured and compared with those of 32 healthy and 33… CONTINUE READING