The death effector domain protein family

@article{Barnhart2003TheDE,
  title={The death effector domain protein family},
  author={Bryan C. Barnhart and Justine C. Lee and Elizabeth C Alappat and Marcus E Peter},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={8634-8644}
}
Apoptosis signaling is regulated and executed by specialized proteins that often carry protein/protein interaction domains. One of these domains is the death effector domain (DED) that is predominantly found in components of the death-inducing signaling complex, which forms at the members of the death receptor family following their ligation. Both proapoptotic- and antiapoptotic-DED-containing proteins have been identified, which makes these proteins exquisitely suited to the regulation of… CONTINUE READING

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