The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.

@article{Lee2003TheDD,
  title={The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.},
  author={Thomas Hun-Tak Lee and Qiaojia Huang and Sarah R. Oikemus and J Elizabeth Shank and Juan-Jos{\'e} Ventura and Nicole Cusson and Richard R. Vaillancourt and Bing Su and Roger J Davis and Michelle A Kelliher},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 22},
  pages={8377-85}
}
The cytokine tumor necrosis factor alpha (TNF-alpha) stimulates the NF-kappaB, SAPK/JNK, and p38 mitogen-activated protein (MAP) kinase pathways by recruiting RIP1 and TRAF2 proteins to the tumor necrosis factor receptor 1 (TNFR1). Genetic studies have revealed that RIP1 links the TNFR1 to the IkappaB kinase (IKK) complex, whereas TRAF2 couples the TNFR1 to the SAPK/JNK cascade. In transfection studies, RIP1 and TRAF2 stimulate p38 MAP kinase activation, and dominant-negative forms of RIP1 and… CONTINUE READING