The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.

@article{Lin2000TheDD,
  title={The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase.},
  author={Yu Hong Lin and Anne Devin and Amy L. Cook and Maccon M. Keane and Michelle Kelliher and Stanley Lipkowitz and Zheng-gang Liu},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 18},
  pages={6638-45}
}
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) (Apo2 ligand [Apo2L]) is a member of the TNF superfamily and has been shown to have selective antitumor activity. Although it is known that TRAIL (Apo2L) induces apoptosis and activates NF-kappaB and Jun N-terminal kinase (JNK) through receptors such as TRAIL-R1 (DR4) and TRAIL-R2 (DR5), the components of its signaling cascade have not been well defined. In this report, we demonstrated that the death domain kinase RIP is… CONTINUE READING

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death and NFk B activation

H. B. Shu
1999

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