The death-associated protein kinases: structure, function, and beyond.

  title={The death-associated protein kinases: structure, function, and beyond.},
  author={Shani Bialik and Adi Kimchi},
  journal={Annual review of biochemistry},
Death-associated protein kinase (DAPk) is the founding member of a newly classified family of Ser/Thr kinases, whose members not only possess significant homology in their catalytic domains, but also share cell death-associated functions. The realization that DAPk is a tumor suppressor gene, whose expression is lost in multiple tumor types, has spurred a flurry of interest in the kinase family and produced an impressive body of literature concerning its function, regulation, and connection to… CONTINUE READING
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