The dearth of new antibiotic development: why we should be worried and what we can do about it

@article{Charles2004TheDO,
  title={The dearth of new antibiotic development: why we should be worried and what we can do about it},
  author={Patrick G. P. Charles and M. Lindsay Grayson},
  journal={Medical Journal of Australia},
  year={2004},
  volume={181}
}
The emergence and spread of multidrug‐resistant pathogens has increased substantially over the past 20 years. Over the same period, the development of new antibiotics has decreased alarmingly, with many pharmaceutical companies pulling out of antibiotic research in favour of developing “lifestyle” drugs. Reasons given for withdrawing from antibiotic development include poor “net present value” status of antibiotics, changes in regulations requiring larger drug trials and prolonged post… 
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