The deadenylation conferred by the 3' untranslated region of a developmentally controlled mRNA in Xenopus embryos is switched to polyadenylation by deletion of a short sequence element.

@article{Bouvet1994TheDC,
  title={The deadenylation conferred by the 3' untranslated region of a developmentally controlled mRNA in Xenopus embryos is switched to polyadenylation by deletion of a short sequence element.},
  author={Philippe Bouvet and Francis Omilli and Yannick Arlot-Bonnemains and Vincent Legagneux and Christian Roghi and Th{\'e}r{\`e}se Bassez and Howard Beverley Osborne},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 3},
  pages={
          1893-900
        }
}
The maternal Xenopus Eg mRNAs are adenylated and translated in the mature oocyte and then, after fertilization, are deadenylated and released from polysomes. Therefore, after fertilization, a change occurs in the cellular mechanisms that control mRNA adenylation. In the study reported here, we show that the 3' untranslated region of Eg2 mRNA contains a cis-acting element that is required for the deadenylation of chimeric RNAs after fertilization. This cis-acting element is contained within a… CONTINUE READING
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