The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80

@inproceedings{Typas2015TheDE,
  title={The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80},
  author={Dimitris Typas and Martijn S. Luijsterburg and Wouter W. Wiegant and Michaela Diakatou and Angela Helfricht and Peter E. Thijssen and Bram van de Broek and L. H. Mullenders and Haico van Attikum},
  booktitle={Nucleic acids research},
  year={2015}
}
The faithful repair of DNA double-strand breaks (DSBs) is essential to safeguard genome stability. DSBs elicit a signaling cascade involving the E3 ubiquitin ligases RNF8/RNF168 and the ubiquitin-dependent assembly of the BRCA1-Abraxas-RAP80-MERIT40 complex. The association of BRCA1 with ubiquitin conjugates through RAP80 is known to be inhibitory to DSB repair by homologous recombination (HR). However, the precise regulation of this mechanism remains poorly understood. Through genetic screens… CONTINUE READING
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