The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila

  title={The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila},
  author={Lisa Koerver and Juliane Melzer and Eva Aguado Roca and Dominic Teichert and Timo Glatter and Eli Arama and Meike Broemer},
  journal={Cell Death and Differentiation},
De-ubiquitylating enzymes (DUBs) reverse protein ubiquitylation and thereby control essential cellular functions. Screening for a DUB that counteracts caspase ubiquitylation to regulate cell survival, we identified the Drosophila ovarian tumour-type DUB DUBA (CG6091). DUBA physically interacts with the initiator caspase death regulator Nedd2-like caspase (Dronc) and de-ubiquitylates it, thereby contributing to efficient inhibitor of apoptosis-antagonist-induced apoptosis in the fly eye… CONTINUE READING
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