The dawn of the RNA World: toward functional complexity through ligation of random RNA oligomers.

@article{Briones2009TheDO,
  title={The dawn of the RNA World: toward functional complexity through ligation of random RNA oligomers.},
  author={Carlos Briones and Michael Stich and Susanna C. Manrubia},
  journal={RNA},
  year={2009},
  volume={15 5},
  pages={
          743-9
        }
}
A main unsolved problem in the RNA World scenario for the origin of life is how a template-dependent RNA polymerase ribozyme emerged from short RNA oligomers obtained by random polymerization on mineral surfaces. A number of computational studies have shown that the structural repertoire yielded by that process is dominated by topologically simple structures, notably hairpin-like ones. A fraction of these could display RNA ligase activity and catalyze the assembly of larger, eventually… CONTINUE READING

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