The dark sides of amyloid in Alzheimer's disease pathogenesis.

  title={The dark sides of amyloid in Alzheimer's disease pathogenesis.},
  author={Pierpaolo Sorrentino and Antonietta Iuliano and Arianna Polverino and Francesca Jacini and Giuseppe Sorrentino},
  journal={FEBS letters},
  volume={588 5},
Although widely explored, the pathogenesis of Alzheimer's disease (AD) has yet to be cleared. Over the past twenty years the so call amyloid cascade hypothesis represented the main research paradigm in AD pathogenesis. In spite of its large consensus, the proposed role of β-amyloid (Aβ) remain to be elucidated. Many evidences are starting to cast doubt on Aβ as the primary causative factor in AD. For instance, Aβ is deposited in the brain following many different kinds of injury. Also… CONTINUE READING
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