The dark side of a success story: microRNAs of the C19MC cluster in human tumours.

@article{Flor2012TheDS,
  title={The dark side of a success story: microRNAs of the C19MC cluster in human tumours.},
  author={Inga Flor and Joern Bullerdiek},
  journal={The Journal of pathology},
  year={2012},
  volume={227 3},
  pages={
          270-4
        }
}
MicroRNAs are a class of macromolecules of rapidly emerging significance for the pathogenesis of numerous human diseases, including cancer. Moreover, many of them hold great promise as valid biomarkers because of their high extracellular stability. Chromosome 19 harbours the largest cluster of microRNA genes known so far, which has developed in a very short time during mammalian evolution. Thus, in terms of evolution, gain of this cluster is an apparent success story. Nevertheless, we know very… CONTINUE READING

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